In a sign that Republicans may sense they are at risk of losing a Senate seat in even the deep-red state of Mississippi, appointed incumbent Roger Wicker (R) has a new ad up introducing himself to voters five months before the election:

Recent polling has shown Wicker in a close race against former Gov. Ronnie Musgrove (D).

In the wake of a surprise House special election victory for the Democrats in the state a couple weeks ago, the possibility that a GOP Senate seat is even in play in Mississippi is a stunning reminder of the extent to which Republicans are on defense all over the map heading into this Fall.